Contents:
NACA - Function. Gold Only. Protein also known as :. Gene name :. NACA ;. Family name :.
Family NAC-alpha. Suggestions for updates are welcome! Please contact us. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. Unregulated exposure of the ribosomal M-site caused by NAC depletion results in delivery of non-secretory polypeptides to the Sec61 complex.
FEBS Lett. NACA is a positive regulator of human erythroid-cell differentiation. The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions.
This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation. Request PDF on ResearchGate | Regulatory Nascent Polypeptides | This book highlights a new paradigm of translation control by regulatory nascent.
M ] [PubMed: ]. Any molecular function by which a gene product interacts selectively and non-covalently with DNA deoxyribonucleic acid. Interacting selectively and non-covalently with any protein or protein complex a complex of two or more proteins that may include other nonprotein molecules. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Immunity 35, [Full text: A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery.
The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator. The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development.
Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. Any process that activates, maintains or increases the rate of skeletal muscle growth. Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development.
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
UniProt Related Accession. P ; Q [ Other Products ]. Molecular Weight. UniProt Protein Name. Nascent polypeptide-associated complex subunit alpha, muscle-specific form. UniProt Synonym Protein Names. Protein Family. Nascent polypeptide-associated complex. UniProt Gene Name. UniProt Synonym Gene Names. UniProt Entry Name. Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle SRP , which normally targets nascent secretory peptides to the ER.
Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane M sites. Belongs to the NAC-alpha family. Both subunits can contact nascent polypeptide chains. Altered gene dosages for Galphas and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost. All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards.
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