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In patients with varying degrees of liver failure alcoholic fatty liver cirrhosis with or without ascites , there was only a slight alteration in the pharmacokinetic properties of Ceftriaxone [29]. The elimination half-life was not increased. The increased unbound fraction of Ceftriaxone contributed to an increase in the volume of distribution, total clearance of the antibiotic, and normal elimination half-life [29]. Thus, cross-reactivity with penicillin antibiotics can occur and Ceftriaxone should not be used in patients who have a history of 54 H.
Ceftriaxone does not contain the 3-tetraolylthiomethyl substituent found in the structure of moxalactam, cefoperazone, and cefamandole. Thus, it is unlikely to elicit the clotting abnormalities reported for these antibiotics. The LD50 of Ceftriaxone in mice and rats is shown in Table 8 [1]. Suryanarayanan University of Minnesota and Mr. Budavari, ed. McEvoy, ed. Mandell and M. Gilman, ed.
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