Autophagy in Mammalian Systems, Part B

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These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes.

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In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth. Toon meer Toon minder.

Introduction

Experimental evidence pointed at autophagy as a pancreatic cancer cell mechanism to survive under adverse environmental conditions or as a defective programmed cell death mechanism that favors pancreatic cancer cell resistance to treatment. On the other hand, clearance of insoluble aggregate-prone proteins require formation of aggresomes. These can lead to mitochondrial swelling and depolarization. This entire panorama gives us a complex but exciting scenario. Schuck, S. S2 Data. The demographics of the ubiquitin system.

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Pathways to Cell Death: Apoptosis, Pyroptosis, and Autophagy

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The Role of Autophagy in Subarachnoid Hemorrhage: An Update

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Autophagy in mammalian systems, Part B. Preface. Klionsky DJ. Animals; Autophagy/physiology*; Biological Assay; Humans; Mammals/metabolism*. Chapter 1 Monitoring Autophagy in Mammalian Cultured Cells through the Dynamics of LC3. Shunsuke Kimura, Naonobu Fujita, Takeshi Noda, Tamotsu.

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The physiological roles of autophagy in the mammalian life cycle

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