Topical and Transdermal Drug Delivery: Principles and Practice

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In addition, the reader is referred to reviews on skin hydration and moisturization available in the literature. Methods to assess and enhance skin permeation are discussed in the following chapters in Part One of this text. Zeeuwen PL. Epidermal differentiation: The role of proteases and their inhibitors. Eur J Cell Biol ; — Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol ; — Br J Dermatol ; 1—7.

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Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement.

References 19 4. Beta4 integrin is required for hemidesmosome formation, cell adhe- sion and cell survival. J Cell Biol ; — The dermal-epidermal junction.

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She has published extensively on her research and holds a number of patents related to transdermal delivery. Regional variation in percutaneous absorption in man: Measurement by the stripping method. Tsai, J. Prior to Perth Dr. Kendall, and Michael S. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Marro, D.

Curr Opin Cell Biol ; 9: — Hearing VJ. Biochemical control of melanogenesis and melanosomal organization. J Investig Dermatol Symp Proc ; 4: 24— Tachibana T, Nawa T. Recent progress in studies on Merkel cell biology. Anat Sci Int ; 26— Tachibana T.

Transdermal drug delivery: principles and opioid therapy | BJA Education | Oxford Academic

Arch Histol Cytol ; — Landmann L. The epidermal permeability barrier.

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Anat Embryol Berl ; 1— Lundstrom A, Egelrud T. Stratum corneum chymotryptic enzyme: A proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation. Acta Derm Venereol ; — Egelrud T. Ekholm E, Egelrud T. Stratum corneum chymotryptic enzyme in psoriasis. Arch Dermatol Res ; — J Invest Dermatol ; 62— Elias PM. Epidermal lipids, membranes, and keratinization.

Int J Dermatol ; 1— Drug permeation through human skin: Theory and in vitro experimental measurement.

AIChE J ; — Nemes Z, Steinert PM. Bricks and mortar of the epidermal barrier. Exp Mol Med ; 5— Lipids are covalently attached to rigid corneocyte protein envelopes existing predominantly as beta-sheets: A solid-state nuclear magnetic resonance study. Omega-hydroxyceramides are required for corneocyte lipid envelope CLE formation and normal epidermal permeability barrier function.

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Wartewig S, Neubert RH. Properties of ceramides and their impact on the stratum corneum structure: A review. Part 1: Ceramides. Skin Pharmacol Physiol ; — Human stratum corneum lipids: Characterization and regional variations. J Lipid Res ; — Characterization of overall ceramide species in human stratum corneum.

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A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction. New aspects of the skin barrier organization. Bouwstra J, Ponec M. The skin in healthy and diseased state. Biochim Biophys Acta ; — Electron diffraction provides new information on human stratum corneum lipid organization studied in relation to depth and tempera- ture.

Chemical enhancement of percutaneous absorption in rela- tion to stratum corneum structural alterations.

Overview on nanotechnology based cosmeceuticals to prevent skin aging

J Control Rel ; — Stratum corneum moisturization at the molecular level: An update in relation to the dry skin cycle. The structure and function of skin. In: Walters KA, ed. Dermatological and Transdermal Formulations.

The Art and Science of Dermal Formulation Development

Marcel Dekker, New York, Morphological and functional aspects. Medicine Baltimore ; — Subcutaneous absorption kinetics and local tissue distribution of interferon and other solutes. J Pharm Pharmacol ; — Photoaging and the skin: Differentiation and clinical response.

Geriatrics ; 36— Structural and functional changes of normal aging skin. J Am Acad Dermatol ; — Skin Res Technol ; 8: — Stratum corneum lipids: The effect of ageing and the seasons. Physiological and morphological changes in facial skin with aging II. J Soc Cosmet Chem Japan ; 22— Regional variation of nonimmunologic contact urticaria.

Functional map of the human face. Skin Pharmacol ; 9: — Skin aging. Effect on transepidermal water loss, stratum corneum hydration, skin surface pH, and casual sebum content. Arch Dermatol ; — Marrakchi S, Maibach HI. Sodium lauryl sulfate-induced irritation in the human face: Regional and age-related differences. Pharmacodynamic measurements of methyl nicotinate percutaneous absorption: The effect of aging on microcirculation. Br J Dermatol ; — Assessment of skin barrier function using transepidermal water loss: Effect of age. Pharm Res ; 6: — Development of skin barrier function in premature infants.

Skin barrier, hydration, and pH of the skin of infants under 2 years of age.

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Pediatr Dermatol ; 93— Barrier function of neonatal skin. J Pediatr ; — Skin barrier properties in different body areas in neonates. Pediatrics ; — Feldman R, Maibach HI. Absorption of some organic compounds through the skin in man. Regional variation in percutaneous absorption in man: Measurement by the stripping method. Biophysical parameters of skin: Map of human face, regional, and age-related differences.

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Contact Dermatitis ; 28— Berardesca E, Maibach HI. Racial differences in sodium lauryl sulphate induced cutaneous irrita- tion: Black and white. Contact Dermatitis ; 65— In vivo evaluation of the stratum corneum barrier function in blacks, Caucasians and Asians with two noninvasive methods. Skin Pharmacol ; 6: — A comparison of black and white skin using non- invasive methods. J Soc Cosmet Chem ; — Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin. J Dermatol Sci ; — References 21 Epidemiology of skin barrier function: Host and environmental factors.

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Dermatologic, Cosmeceutic and Cosmetic Development. Informa Healthcare, New York, ; — Frictional properties of human skin: Relation to age, sex and anatomical region, stratum corneum hydration and transepidermal water loss.