Chemical Carcinogens: Some Guidelines for Handling and Disposal in the Laboratory

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Approval will be granted only in exceptional cases, and only when particulate handling e. Refer to Chapter 5: Protective Clothing and Equipment. Wear a full-fastened laboratory coat or a disposable jump suit in any area where highly toxic chemicals or select carcinogens are in use. The Principal Investigator is to provide clean clothing weekly and you cannot wear it outside of the work area. Following an obvious exposure, decontaminate or dispose immediately all clothing contaminated by highly toxic chemicals.

Do not send contaminated clothing to the laundry until decontaminated. Wear appropriate gloves Appendix 5-B when handling. Double gloving is recommended. Discard disposable gloves after each use and immediately after known contact with a highly toxic chemical or select carcinogen. Procedures involving volatile chemicals, and those involving solid or liquid chemicals that may result in the generation of aerosols, must occur in a laboratory hood, glove box, or other suitable containment equipment.

Examples of aerosol-producing procedures include: opening of closed vessels; transfer operations; weighing; preparing feed mixtures; and the application, injection or intubation of a chemical into experimental animals. Class II, type B biological safety cabinets are suitable for the conduct of tissue culture and other biological procedures involving highly toxic chemicals, reproductive toxins, and select carcinogens. For more information on biological safety cabinets, refer to Chapter Biological Safety Cabinets.

The examples below in Figure 7. Figure 7. A clean bench Chapter 16, Section III is a laminar flow cabinet that provides a flow of filtered air over the work service and offers product protection, not personnel protection.

Do not use highly toxic chemicals or select carcinogens in them. These are posted by the lab or EHS with the information in Figure 7. Analytical instruments, when used with highly toxic chemicals and select carcinogens, must be located entirely within a laboratory hood. When this is impossible, capture the vapors or aerosols produced by these instruments through local exhaust ventilation at the site of their production. When you remove a sample from the analytical instrument, place it in a tightly stoppered sample tube, or otherwise safeguarded from contaminating the laboratory.

Do not use contaminated analytical equipment until it has been completely decontaminated. The following are some decontamination guidelines.

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Contact EHS if you have additional questions about equipment decontamination. Safely remove, drain, or discharge chemicals from the equipment, collecting the chemicals for re-use or hazardous waste disposal. If applicable, use an inert gas or liquid to purge the chemical residues. In some cases, the rinsate might require disposal as hazardous waste. For equipment with non-permeable surfaces, decontaminate by scrubbing with warm, soapy water.

For equipment that also might contain biological contamination, follow the soapy water wash with a bleach solution soak. Rinse the equipment after at least 10 minutes contact time with the bleach. Stock quantities of chemical carcinogens are to be stored in designated storage areas.

Keep quantities of highly toxic chemicals, and select carcinogens in the work area to a minimum. Quantities should not exceed the amounts normally required for use in one week. Use the label depicted in Figure 7. Place storage vessels containing highly toxic chemicals or select carcinogens in an unbreakable outer container before transporting them from storage areas to laboratory work areas.

Place contaminated materials to transfer from work areas to disposal areas in a closed plastic bag or other suitable impermeable and sealed primary container, and place the primary container in a durable outer container before transporting. Label the outer container with both the name of the substance and the warning from Figure 7. Each vacuum service, including water aspirators, must have protection via an absorbent or liquid trap and a HEPA filter to prevent entry of any highly toxic chemical or select carcinogen into the system.

When using a volatile chemical, use a separate vacuum pump or other device placed in an appropriate laboratory hood.

Package highly toxic chemicals and select carcinogens to withstand shocks, pressure changes and any other condition that could cause the leakage of contents incident to ordinary handling during transportation. These regulations state that you must receive specific training in order to ship a hazardous chemical legally. Contact EHS to receive this training and for guidance on shipping and labeling.

Highly toxic chemicals and select carcinogens that have spilled out of a primary container to create a hazard must be inactivated in situ or absorbed by appropriate means for subsequent disposal. Contaminated materials require decontamination by procedures that decompose the chemical, or removal for subsequent disposal. Write these decontamination protocols into your Laboratory Safety Plan, and update the protocols as necessary. Means for assuring the adequacy of clean up are required; for instance, wipe tests or fluorescence tests. EHS must approve all plans for handling and ultimate disposal of contaminated wastes.

Refer to Chapter Management of Laboratory Wastes for additional guidance. In all circumstances, research and animal care personnel must wear a disposable jumpsuit or lab coat, shoe coverings, hair covering, gloves, and a respiratory comfort mask when entering Division of Comparative Medicine DCM; formerly the Division of Laboratory Animal Medicine DLAM animal housing facilities or procedure rooms refer to Chapter Safe Handling of Laboratory Animals. As discussed in Chapter 5, comfort masks and surgical masks are not respirators.

Carcinogens

The comfort masks and surgical masks provided in several DCM facilities do not protect you from airborne exposures; instead, they protect the lab animals from your exhalations. Personnel engaged in procedures with exposure to airborne particulates contaminated with highly toxic chemicals or select carcinogens must wear an appropriate respirator of N95 or higher protection, rather than a comfort mask or surgical mask.

Refer to the Respiratory Protection section of Chapter 5: Protective Clothing and Equipment , for a description of respirator types. The use of primary containment may eliminate the need to wear a respirator. Do not wear masks or respirators outside of the animal room or procedure room. The Bloodborne Pathogens Program is designed to address and reduce the risk of injury. Because workers are at risk daily, sharps e. Sharps and Laboratory Glass Disposal.

Appendix A. Disposal Procedures by Chemical This is an alphabetical list of chemicals and their corresponding disposal procedures found in Chapter 7. Appendix B. Appendix C. This appendix is a template that you can easily complete and generate a Chemical Hygiene Plan for you lab.

Chemical Carcinogens - Environmental Health & Safety - University of Delaware

Annex C Appendix D. Particularly Hazardous Substances The OSHA Laboratory Standard law requires additional precautions for the use of particularly hazardous substances, which are listed in this appendix. Select Carcinogens with footnote Annex D Appendix E. Laboratory Safety Survey Periodic laboratory safety surveys will help you maintain a safe laboratory. Use this checklist to review the safety status of you lab. Insure deficient areas are addressed during routine laboratory meetings.

Guide Chemical Carcinogens: Some Guidelines for Handling and Disposal in the Laboratory

Appendix F. Preventing Chemical Incompatibility Hazards When combined, incompatible chemicals can generate a toxic gas, start a fire, or cause an explosion. Careful chemical storage is also important to prevent incompatibility problems in a fire. Appendix G. Appendix H.

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You will comply with the law by following the disposal procedures in Part G. Appendix I. Here are some musings from our chemist which may prove useful. Appendix J. Answers to Review Questions Here you can see what we thought were the correct answers.

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