PDF Targeted Therapies: Mechanisms of Resistance

Drug resistance and combating drug resistance in cancer

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Contents:

Targeted Therapies

Targeting driver oncogenes in lung adenocarcinoma

Targeted Therapy Resistance: Mechanism

Mechanisms of Resistance

Mechanism of resistance to BRAF inhibitors in melanoma identified

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Targeted Therapies

Share This Paper. Figures and Topics from this paper. Citations Publications citing this paper. References Publications referenced by this paper. J Hematol Oncol ; Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity.

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Targeting driver oncogenes in lung adenocarcinoma

Handb Exp Pharmacol. ; doi: /__ Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer. Facchinetti. A major limitation of targeted anticancer therapies is intrinsic or acquired resistance. This review emphasizes similarities in the mechanisms of.

Dysregulated pH: a perfect storm for cancer progression. Drug resistance and cellular adaptation to tumor acidic pH microenvironment. Mol Pharm ; Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma. The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas.

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Twist mediates an aggressive phenotype in human colorectal cancer cells.

Targeted Therapy Resistance: Mechanism

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer. BMC Cancer ; The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance. J Cancer ; FOXC2 promotes chemoresistance in nasopharyngeal carcinomas via induction of epithelial mesenchymal transition. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

Mechanisms of Resistance

Allegra CJ. Cancer Cell. Lung cancer was most commonly diagnosed, and the leading cause of cancer-related death followed by breast, prostate, colorectal, stomach, and liver cancer [ 1 ]. Cortot, A. Prostate Cancer. The next section addresses a new field in targeted cancer therapy that aims to improve on molecularly targeted therapies by embedding further selectivity into therapeutics. J Clin Oncol 22 15 ,

Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters. Cell Death Dis ;2:e Short hairpin RNA targeting Twist1 suppresses cell proliferation and improves chemosensitivity to cisplatin in HeLa human cervical cancer cells. Oncol Rep ; A critical dose of doxorubicin is required to alter the gene expression profiles in MCF-7 cells acquiring multidrug resistance.

Overexpression of Snail accelerates adriamycin induction of multidrug resistance in breast cancer cells.

Mechanism of resistance to BRAF inhibitors in melanoma identified

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Tumour Biol ; Cancer Genet ; Down-regulation of miRa might reverse multidrug resistance of esophageal squamous cell carcinoma.

Targeted treatment with EGFR TKIs: Front line options

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