Antisense Drug Technology: Principles, Strategies, and Applications

EP2742056B1 - Selektive antisense-verbindungen und ihre verwendungen - Google Patents
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  • Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition

    • Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery.

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    A Part three details hybridization based drugs and considers the dramatic advances represented by 2a TM methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs.

    The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.

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    Summary. Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic. Abstract CRC Press, Boca Raton xvii+ pp., hardcover $ —ISBN ‐0‐‐‐8 CRC Press, Boca Raton xvii+

    Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology. This book gives a nearly complete overview of the current state-of-the-art oligonucleotide drugs.

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    Ref country code : CY. Lancet , — Would you like to tell us about a lower price? Next, we identified the major sites of subcellular accumulation and characterized the kinetics, with which these sites accumulate PS ASOs after transfection, free uptake, and electroporation [ 12 , 13 , 15 , 18 , 19 ]. Effective date : EPA4 de.

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    Antisense Drug Technology Principles, Strategies, and Applications, Second Edition

    Pharmacokinetic Properties in Humans. SerineThreonine Protein Phosphatases. Toxicity of Antisense Oligonucleotides.

    Clinical Safety of Phosphorothioate Oligodeoxynucleotides. General Pharmacology of Phosphorothioate Oligodeoxynucleotides.

    • Antisense Drug Technology: Principles: Strategies, and Applications - Google книги.
    • Antisense Technology | SpringerLink.
    • Ultrasonography of the Neck.
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    • Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition!

    Pharmacology of Methoxyethyl Modified Antisense Oligonucleotides.