Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3

EMBL - European Molecular Biology Laboratory

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Organic chemistry: Molecular diversity by design. The state of the art of chemical biology. Chembiochem : a European Journal of Chemical Biology. Macrocycloadditions leading to conformationally restricted small molecules Organic Letters 8 Organic Letters. Csh Protocols. Sample Purification. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway. Perturbational profiling of nanomaterial biologic activity. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Large-scale chemical dissection of mitochondrial function. Small-molecule reagents for cellular pull-down experiments. Towards the optimal screening collection: a synthesis strategy.

ChemBank: a small-molecule screening and cheminformatics resource database. Large-scale chemical dissection of mitochondrial function Nature Biotechnology 26 Nature Biotechnology. Histone Variant H2A. Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis. Journal of Combinatorial Chemistry. Complex alpha-pyrones synthesized by a gold-catalyzed coupling reaction.

Refereed Papers In Primary Journals

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors. Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Evolutionarily conserved optimization of amino acid biosynthesis. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrobial Agents and Chemotherapy. Journal of Computer-Aided Molecular Design.

Rethinking relationships between natural products. Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Related Organisations

Multilevel regulation of growth rate in yeast revealed using systems biology. Journal of Biology. Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening. Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.

BBSP Faculty | UNC BBSP

Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nature Genetics. Synthesis and cellular profiling of diverse organosilicon small molecules. A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication.

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A microarray-based protocol for monitoring the growth of yeast overexpression strains. Nature Protocols. An oligomer-based approach to skeletal diversity in small-molecule synthesis. Using high-throughput screening data to discriminate compounds with single-target effects from those with side effects. Journal of Chemical Information and Modeling. A robust small-molecule microarray platform for screening cell lysates.

SearchWorks Catalog

Query Chem: a Google-powered web search combining text and chemical structures. Macrocycloadditions leading to conformationally restricted small molecules. Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions. Revealing complex traits with small molecules and naturally recombinant yeast strains.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway Nature Chemical Biology. Enantioselective addition of terminal alkynes to isolated isoquinoline iminiums. Small molecules: the missing link in the central dogma.

2.1 Design of Sequence-Specific DNA-Binding PIP Fluorescence Conjugates.

Identifying biologically active compound classes using phenotypic screening data and sampling statistics. Histone variant H2A. Z marks the 5' ends of both active and inactive genes in euchromatin.

Deparmental Seminar Archive

SpectralNET--an application for spectral graph analysis and visualization. Bmc Bioinformatics. Single-nucleosome mapping of histone modifications in S. Plos Biology. From solution-phase to solid-phase enyne metathesis: crossover in the relative performance of two commonly used ruthenium pre-catalysts.

Small-molecule diversity using a skeletal transformation strategy.

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Convergent diversity-oriented synthesis of small-molecule hybrids.

Using genome-wide transcriptional profiling to elucidate small-molecule mechanism.

Genomic maps and comparative analysis of histone modifications in human and mouse. Skeletal diversity via a folding pathway: synthesis of indole alkaloid-like skeletons. A library of spirooxindoles based on a stereoselective three-component coupling reaction. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.

Finding new components of the target of rapamycin TOR signaling network through chemical genetics and proteome chips.

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. Stereochemical control of the Passerini reaction. A synthesis strategy yielding skeletally diverse small molecules combinatorially. Syntheses of stereochemically diverse nine-membered ring-containing biaryls. Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Global nucleosome occupancy in yeast. Genome Biology. Identification of Ald6p as the target of a class of small-molecule suppressors of FK and their use in network dissection.

Rpd3p relocation mediates a transcriptional response to rapamycin in yeast. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates. Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization.

The use of chromatin immunoprecipitation assays in genome-wide analyses of histone modifications. Methods in Enzymology. A planning strategy for diversity-oriented synthesis.

Small molecule modulation of the human chromatid decatenation checkpoint. Generating diverse skeletons of small molecules combinatorially. Stereochemical control of skeletal diversity. Integration of growth factor and nutrient signaling: implications for cancer biology. Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations. Development of a versatile stepwise, three-component reaction for diversity-oriented synthesis.

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