Immune Reactivity of Lymphocytes: Development, Expression, and Control

What is "Self-Tolerance"?
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Immunity to HIV 6. Thymic T Cell Development 7.

Systems Vaccinology 2. Vaccine Development 3. Adjuvants 4.

T Lymphocytes and Cellular Immunity | Microbiology

DNA Vaccines 5. Mucosal Vaccines 6. Infant Immunity and Vaccines 2. Dendritic Cells 3. Conventional T Cells 4. Immunity to Viral Infections 6.

T Lymphocytes and Cellular Immunity

Immunity to Helminth Infections 7. Immunity to TB 8.

Self Recognition

All the ex vivo biological experiments described were conducted in a Biosafety Level 2 containment facility and were approved by the institutional biosafety committee of National University of Singapore. The superantigen in these mice is a protein encoded by a mouse mammary tumor virus MMTV gene which has become integrated into the mouse genome and is inherited along with the mouse genes and expressed as self peptides. Positive selection was demonstrated in radiation chimeras also called bone marrow chimeras , mice whose hematopoietic cells had been destroyed by irradiation and replaced by hematopoietic cells from another mouse strain. Zhou, P. Nat Immunol 13 5 —8.

Immunity to Malaria 9. Introduction to Immunization Strategies 2. Immune Responses to Vaccination 3. Models for Testing Vaccines 4. Immune Escape 5.

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Neutrophils 2. Exosomes 4. Immunity to Leishmania 6. Immunity to HIV 7. Immunity to Helminth Infections 8. Immunity to TB 9. Cancer Epidemiology and Etiology 2. T lymphocyte mediated immunity 3.

1 INTRODUCTION

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  3. Introduction.
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Tumor Microenvironment 6. Pathogens and Cancer 7. Cancer Immunotherapy 8. Overview of the Immune System 2.

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1

These findings provide evidence that at a cellular and protein level RES could negatively regulate the apoptosis of chicken peripheral lymphocytes induced by LPS. The results of this study could provide valuable theoretical evidence and a practical contribution to the determination of the exact regulation mechanisms of lymphocyte apoptosis caused by stress. Ashutosh K, Shyam S, NF-kB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy.

Biochemical and Biophysical Research Communications ; Influenza A whole virion vaccine induces a rapid reduction of peripheral blood leukocytes via interferon-a-dependent apoptosis. Vaccine ; Oncogene ; Lipopolysaccharide-induced oxidative stress in the liver: comparison between rat and rabbit. Shock ; Altered monocyte and macrophage numbers in blood and organs of chickens injected i.

Veterinary Immunology and Immunopathology ; Finlay BB, Cossart P. Exploitation of mammalian host cell functions by bacterial pathogens. Science ; Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochemical Pharmacology ; Effects of resveratrol on the G0-G1 transition and cell cycle progression of mitogenically stimulated human lymphocytes. Lappin E, Ferguson AJ. Gram-positive toxic shock syndromes. Lancet Infectious Diseases ; Nature ; Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis:potential role of reactive oxygen intermediates and lipid peroxidation.

Journal Immunology ; Microbiology Letters ; Effects of dietary resveratrol supplementation on egg production and antioxidant status. Poultry Science ; Resveratrol protects quail hepatocytes against heat stress: modulation of the Nrf2 transcription factor and heat shock proteins. Journal of Animal Physiology and Animal Nutrition ; Resveratrol attenuates methylglyoxal-induced mitochondrial dysfunction and apoptosis by Sestrin2 induction[J]. Toxicology and Applied Pharmacology ; 2 Resveratrol suppresses interleukin-1b-induced inflammatory signaling and apoptosis in human articular chondrocytes:potential for use as a novel nutraceutical for the treatment of osteoarthritis[J].

Biochemical Pharmacology ;76 11 Bryden WL Differential alterations in ultrastructural morphology of chicken heterophils and lymphocytes induced by corticosterone and lipopolysaccharide. Nature — Groom JR. Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory.

Immunol Cell Biol 93 4 —6. Immunity 37 6 — Nat Immunol 13 7 — B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J Exp Med 7 — Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo. Disruption of pathogenic cellular networks by IL blockade leads to disease amelioration in murine lupus.

J Immunol 7 — J Immunol 4 —8. J Exp Med 8 — J Clin Invest 1 — T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity 29 2 — Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity. Curr Opin Immunol 24 6 — Tarlinton D, Good-Jacobson K. Diversity among memory B cells: origin, consequences, and utility. Humoral immunity. T cell help controls the speed of the cell cycle in germinal center B cells. Science —6. Clonal selection in the germinal centre by regulated proliferation and hypermutation.

Dynamic signaling by T follicular helper cells during germinal center B cell selection. B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity. J Exp Med 11 — Nat Commun 8 1 Interferon-gamma excess leads to pathogenic accumulation of follicular helper T cells and germinal centers. Immunity 37 5 — A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.

Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity 38 4 — Follicular helper T cells are required for systemic autoimmunity. J Exp Med 3 — Clonal evolution of autoreactive germinal centers. The microanatomic segregation of selection by apoptosis in the germinal center.