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The dotted line indicates the predicted survival curve of a particular mutant strain cultured with PE4 if this PE exhibits an additive longevity-extending effect with the mutation. Data for the mock-treated WT strain are replicated in all graphs of this Figure and in all graphs of Figure 4. Data for each of the mock-treated mutant strains presented in this Figure are replicated in the corresponding graphs of Figure 4.
The effect of PE4 on the signaling pathways and protein kinases comprising the longevity-defining network. This effect is inferred from the data presented in A. S1 and S7. Abbreviations: as in the legend to Figure 1. Figure S2. Figure S8; note that data for the mock-treated WT strain and for the WT strain cultured with PE5 are replicated in all graphs of this figure.
Figure S8. One of these branches involves the Rimindependent processes of autophagy inhibition and protein translation activation in the cytosol, whereas the other branch attenuates the Rimdiven establishment of an anti-aging transcriptional program of numerous nuclear genes [ 8 , 11 , 34 , 40 , 61 , 62 , 66 , 69 , 72 , 73 , 84 - 86 ].
The dotted line indicates the predicted survival curve of a particular mutant strain cultured with PE5 if this PE exhibits an additive longevity-extending effect with the mutation. Data for the mock-treated WT strain are replicated in all graphs of this Figure and in all graphs of Figure 3. Data for each of the mock-treated mutant strains presented in this Figure are replicated in the corresponding graphs of Figure 3.
The effect of PE5 on the signaling pathways and protein kinases comprising the longevity-defining network. S2 and S8. Figure S3.
Figure S9; note that data for the mock-treated WT strain and for the WT strain cultured with PE6 are replicated in all graphs of this figure. S3 and S9. Survival curves of chronologically aging WT and mutant strains cultured with or without 1. The dotted line indicates the predicted survival curve of a particular mutant strain cultured with PE6 if this PE exhibits an additive longevity-extending effect with the mutation. These effects are inferred from the data presented in A. Figure S4. Figure S10; note that data for the mock-treated WT strain and for the WT strain cultured with PE8 are replicated in all graphs of this figure.
Figure S The dotted line indicates the predicted survival curve of a particular mutant strain cultured with PE8 if this PE exhibits an additive longevity-extending effect with the mutation.